Ahangama Arachchige Nilanga
University
Title: Single injection autologous Platelet-rich plasma (PRP) injection for Knee joint osteoarthritis
Biography
Biography: Ahangama Arachchige Nilanga
Abstract
Introduction
PRP is an autologous blood product that is created by first obtaining a small amount of blood through peripheral venesection, concentrating that blood sample through centrifugation, and then administering the concentrated plasma product back into the patient via an intra-articular (IA) injection. Autologous platelet-rich plasma has emerged as a treatment option for treatments for osteoarthritis.
Objective
The aim of this study is to evaluate the efficacy of single PRP injection to reduce the severity of OA in Knee joint
Methods
Thirty three patients with primary and secondary knee osteoarthritis who met the study criteria received single platelet-rich plasma injections in the affected knee at medical unit, Teaching Hospital, Batticaloa during the year 2018. Severity of the OA was assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMc) just before, one month, three months and six months after the PRP injection. Paired sample t-test was used for data analysis.
Results
There were 33 patients with Osteoartirtis. Mean age of the patients was 61.3 (S.D. 12). Osteoarthritis grade 1 to 4 was 9.1%, 48.5%, 30.3% and 12.1% consecutively. Mean Western Ontario and McMaster Universities Osteoarthritis Index (WOMc) score at presentation was 65.2 (59-71). One month, three months and six months WOMc scores were 25 (17-33), 24 (14-34), 24 (13-35) respectively. Paired sample t-test showed a significant improvement in WOMc score in 1 month (p<0.001), 3 months (p< 0.001), and 6 months (p<0.001). But there was no significant improvement from 1 month to 6 month post PRP injections. No PRP injection specific complications were reported.
Discussion
Single injection PRP is a good and reliable option to relive the symptom and sign burden in order to reduce the severity and suffering from KJ OA. Age and initial OA severity is not affect the outcome of PRP injection. Six monthly PRP injections can be a justifiable option as WOMc index starts to show a rise in severity even-though it is not statistically significant.
