Luz M. Herrero Manley
Ana Alabajos Cea, MD, Hospital la Fe, Spain Juan Alonso Perez-Barquero, MD, Hospital la Fe, Spain Enrique Viosca Herrero, PhD, Hospital la Fe, Spain
Title: OACTIVE: ADVANCED MULTI-SCALE COMPUTER MODELS PREVENTING OSTEOARTHRITIS
Biography
Biography: Luz M. Herrero Manley
Abstract
The OActive project is a European project that studies knee OA. It intends to make a significant leap forward adopting a multi-scale holistic analysis where patient-specific information from various levels, including molecular (e.g. biochemical/inflammatory biomarkers), cell, tissue and whole body, will be integrated and combined with information from other sources such as, environmental, behavioural and social risk factors to generate robust predictors for new personalised interventions for delaying onset and/or slowing down progression of OA.
OActive targets patient-specific OA prediction and interventions by using a combination of mechanistic computational models, simulations and big data analytics. Once constructed, these models will be used to simulate and predict optimal treatments, better diagnostics, and improved patient outcomes, overcoming the limitation of the current treatment interventions, Augmented Reality (AR) empowered interventions will be developed in a personalised framework allowing patients to experience the treatment as more enjoyable, resulting in greater motivation, engagement, and training adherence. The AR element will also be helpful for the therapists for validating the patients’ progress and allow them a more adaptive rehabilitation therapy in terms of flexible interactive content.
Objetives:
The OActive scientific and technological objectives focus on the development of computer-based predictive models and simulation for understanding the onset and progression of a major disease like OA.